2005-2006 Research Funded by YTCAF
Each year the AKC Canine Health Foundation send the YTCA Foundation a list of grant requests for funding that they have screened and think would be of interest to breeders and owners of Yorkshire Terriers as well as dog fanciers in general. As an independent entity spun off from the Parent club to preserve our tax exempt status, the YTCAF receives no financial support from the YTCA's participating in efforts such as the Purina Circles program. Instead all of our funding comes from memorials made by individual donors and fund raising efforts such as the online auctions and breeding calendar sales.
The Board members carefully considered these factors in each of the requests in order to optimize research dollars:
Potential of the research to benefit Yorkshire Terriers in particular and all dogs in general.
Previous research success of the primary investigators
Use of the grant project to help veterinary students, new veterinarians and academicians get started in their chosen field of research (Acorn projects).
The Board voted to support the following CHF grants for 2005 - 2006.
CHF Grant Acorn 607-A: Transplenic Portal Scinitigraphy (TSPS) as a Minimally Invasive Technique Under Light Sedation to Clearly Delineate the Portal System
University of Tennessee
Karen Tobias, DVM, DACVS and Patricia A. Sura, DVM
This grant has been completed.
This prospective study performed at the University of Tennessee was designed to compare two different scinitigraphic methods for the diagnosis of portosystemic shunts (PSS) in dogs. PSS are abnormal blood vessels that allow blood to circulate through the body without being detoxified by the liver, resulting in severe clinical signs.
Classically, per-rectal portal scinitigraphy has been performed (PRPS). This test is very sensitive in detecting whether an animal has a shunt. However, it does not yield any information regarding the location of the shunt, or whether more than one shunt is present. This information would be extremely helpful for surgical planning, as most dogs with congenital PSS are small or toy breeds that suffer from low blood sugar, low temperatures, and low blood pressure during surgery. Prior knowledge of shunt location may improve the efficiency of the operative procedure, thereby shortening anesthetic times and resulting in a safer procedure for the patient.
Trans-splenic portal scinitigraphy (TSPS) is a technique developed at UY that involved injecting a small amount of radionuclide into the spleen. Rather than rely on rectal absorption as with PRPS, the nuclide is placed directly into the bloodstream. This results in a much clearer picture of the portal vasculature. Our results thus far indicate that TSPS is 100% sensitive in diagnosing PSS in dogs. Data regarding the ability of TSPS to determine shunt number and location is still being analyzed.
An advantage of TSPS over PRPS is that the test required much less radioactive material to perform. This is safer for the patient, as well as the staff caring for the pet. Significantly less (P<0.001) radiation was required to perform TSPS versus PRPS in the patients in this study.
Preliminary conclusions are that TSPS is as sensitive as PRPS for the diagnosis of PSS in dogs, and that TSPS results in a higher quality study than PRPS. In addition, TSPS required significantly less radioactive materials than PRPS. Future conclusions regarding the accuracy of TSPS and PRPS for determining shunt number and location are expected.
This research has been published: Vet Surg, 2007, Oct.;36(7): 654-60.
CHF Grant 2434: Recombinant Thyrotropin (TSH): Standard for the Next Generation of Canine TSH Immunoassays with Improved Sensitivity
University of Georgia
Duncan Ferguson, DVM, PhD
This research grant has been completed, but the Principal Investigator was unable to reach his goals. This happens in research.
CHF Grant 1943: Congenital Portosystemic Shunts and Hepatoportal Microvascular Dysplasia in Cairn Terriers and Yorkshire Terriers: Clinical Characterization and DNA Linkage Studies
Susan Johnson, DVM and Dr. Vilma (Principal Investigators)
University of Ohio in conjunction with Michigan State University